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KMID : 0616620040100010171
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Journal of Soonchunhyang Medical College
2004 Volume.10 No. 1 p.171 ~ p.176
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Expression of the p53 and Ki-67 in intradermal nevus, junctional nevus and malignant melanoma
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Lee Jung-Hun
Yang Seoung-Ha
Oh Mee-Hye
Kim Eui-Han
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Abstract
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The authors analyzed immunohistochemical expression of mutant p53 and Ki-67 in eleven cases of intradermal nevus, 7 cases of junctional nevus and 6 cases of malignant melanoma, so following results were obtained.
Results: 1. The positive reaction of p53 protein was 0%(0/11) in intradermal nevus, 43%(3/7) in junctional nevus and 83%(5/6) in malignant melanoma. 2. The positive reaction of Ki-67 was 9%(1/11) in intradermal nevus and 14%(1/7) in junctiona nevus, but the labelling index were below 10% in both nevi. In malignant melanoma, the positive reaction of Ki-67 was appeared in 50% (3/6). but the labelling index were below 20% in all positive cases Above results suggested that the p53 expression was stronger in poor differentiated tumors, so the p53 protein expression appeared to be related to the histological differentiation degree. But the Ki-67 expression appeared to be more related to the prognosis according to tumor growth rate than histological differentiation degree Because the Ki-67 labelling index was low in malignant melanoma as expected, it was difficult to justify the idea that the growth and prognosis of malignant melanoma were justified only by the Ki-67 positive reaction and labelling index. But the Ki-67 positive cells were not almostly observed in intradermal nevus and junctional nevus, So the differnetial diagnosis between benign and malignant melanocytic tumors were appeared to be possible by Ki-67 positive reaction and labelling index.
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